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    One of the greatest triumphs of recent medicine continues to be the development of a rational system of antimicrobial chemotherapy to combat infectious diseases. Since time immemorial, folk remedies have exploited moulds or mould extracts to take care of infections. In the early days of microbiology, attempts were designed to use extracts produced by fungal cultures to stop surgical wound infection. Joseph Lister used cultures of his or her own urine to look into the microbiology of air. He noted if moulds were seen in his cultures, the bacteria that had been and also appeared non-motile and degenerate, whereas if bacteria grew without moulds, these were highly motile. Lister determined that moulds produced an ingredient or substances that adversely affected the viability of bacteria. He then reasoned that culture filtrates extracted from moulds should prevent infection if utilized to irrigate surgical wounds. In its modern-day use, it refers primarily to cytotoxic drugs used to manage cancer.

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